In situ Genetic Markers for Leukaemia

IX. Chronic lymphocytic leukaemia: new genetic markers as prognostic factors.

In Western countries, chronic lymphocytic leukaemia (CLL) is the most frequent mature B-cell malignancy [1]. The course of CLL ranges from very indolent, with a nearly normal life expectancy, to rapidly progressive leading to early death. Understand the genetic basis of CLL may help in clarifying the molecular determinants of this clinical heterogeneity and improve patients’ prognostication. Re...

Inherited Genetic Markers for Thrombophilia in Northeastern Iran (a Clinical-Based Report)

Background: Thrombophilia is a main predisposition to thrombosis due to a procoagulant state. Several point mutations play key roles in blood-clotting disorders, which are grouped under the term thrombophilia. These thrombophilic mutations are methylenetetrahydrofolate reductase (MTHFR, C677T, and A1298C), factor V Leiden (G1691A), prothrombin gene mutation (factor II, G20210A), and plasminogen...

A comparative analysis of ISSR and RAPD markers for studying genetic diversity in Iranian pistachio cultivars

Pistachio is one of the most important horticultural products of Iran. The best way to get the maximum yield is to have genetically pure and monotonous gardens. Thereby, study of genetic variation and providing genetic identifications, make this possible to have homogenous gardens with high performance genotypes. In the present study, genetic diversity of 19 Iranian pistachio cultivars was asse...

Detection of genetic prognostic markers in uveal melanoma biopsies using fluorescence in situ hybridization.

PURPOSE In uveal melanoma, specific chromosomal abnormalities are known to correlate with the risk of metastases; changes in chromosomes 3 and 8q correlate strongly with a decreased survival of the patient, whereas chromosome 6 abnormalities are associated with a better prognosis. Usually, karyotyping and fluorescence in situ hybridization (FISH) analysis are used to detect these abnormalities ...

Diagnostics of Molecular Markers in Childhood Acute Leukaemia Using Biochips